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  One factor, however, appears difficult to disentangle even in Campos' meticulously detailed account. We have a fairly low-resolution understanding of what "marijuana use" looked like in Mexico and the U.S. at the turn of the century — how much people consumed, how they ingested it, what substances it might have been combined with. Someone smoking a joint packed half with tobacco and half with cannabis indica (the version of the drug that typically produces a sedentary, mellow high) would have had a very different experience than someone who's drinking the Mexican liquor pulque and eating something laced with cannabis sativa (the version of the drug likelier to produce anxiety).